Running Projects

Bioengineered three-dimensional design to promote neuronal regeneration

Nerve injuries are common and full recovery is challenging. The available therapeutic interventions mostly rely on surgical procedures, which cannot guarantee complete regeneration of the injured nerve and sufficient restoration of function. Among other factors, the slow rate of axonal growth hampers the functional recovery. Development of new approaches to

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Deep learning for real-time Fetal ECG monitoring

Fetal ECG is the leading tool to analyze and detect abnormalities during fetal development. For example, to identify fetal distress and intrauterine hypoxia. Currently, the most common method to monitor a fetus, especially during labor is through fetal monitoring, which is based on auscultation, though there are more accurate methods,

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Human-sperm-cell full refractive-index mapping via ultra-rapid cell 3D tomography

Human sperm quality constantly declines, resulting in a worldwide fertility crisis. We will develop a new multidisciplinary microscopy approach for ultra-rapid 3D label-free fine-detailed imaging of live sperm cells during free swim without staining, with pioneering technological capabilities and revolutionary clinical implications. Our approach is based on optical interferometric tomography

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Bio-Convergence to Detect Plant Stress

We propose a new paradigm for data-driven precision agriculture, using bio-convergence-based functional sensors to directly detect plant stress. The ever-increasing global population, combined with reducing agricultural efficacy due to climate change poses a significant challenge to meeting the world’s food requirements. Technological advances, in particular advances in agricultural sensor technology,

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MXene-based Bio-scaffold for Continuous Monitoring of Skin Regeneration

The proposed project is part of an ongoing interdisciplinary collaboration between the Adler-Abramovich and Sokol research groups at Tel-Aviv University. Prof. Lihi Adler-Abramovich is the head of the Laboratory of Bioinspired Materials and Nanotechnology at the School of Dental Medicine, Faculty of Medicine, which focuses on mimicking self-assembly processes that

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Modeling complex blinding human disease AMD in an engineered tissue – to uncover disease mechanisms and develop personalized treatments.

Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment in older people. Susceptibility to AMD is dependent on a combination of genetic components and environmental factors with role attributed to retinal pigmented epithelium (RPE), immune cells and vasculature. Several genome-wide association studies (GWASs) have been applied to

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Development of a novel pulsed electric field generator and a handheld syringe and needle holder with embedded electrodes for electroporation and electroextraction of biological molecules from the tissue

Current solid tissue sampling methods for diagnostics mostly use tissue biopsy, which could lead to localized tissue injury, bleeding, and scarring. Tissue biopsy is followed by pathological examination of the sampled tissue and a decision based on that examination. Recently, we demonstrated novel technology for harvesting biomolecules in vivo based

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Pupillometry in clinical settings

The human eye can be described as an optical system; The eye focuses and processes incoming light through the lens and the retina . The pupil, an opening in the ring shaped iris, optimizes retinal illumination. Pupil size is modulated by two factors: by the level of ambient light, and

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An integrated engineering-computational-biological approach to unravel molecular dysfunction in Parkinson’s disease

In this cross-campus proposal, we set out to develop a human-relevant in vitro platform for studying Parkinson’s disease (PD), and to use it for identifying PD-associated abnormal pathways using patient-specific differentiated cells. Over the first six months, we developed the computational, biological, and engineering infrastructure for tackling this goal, advancing

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